Corneodesmosin is an epidermal glycoprotein and defects in its gene are manifested as the inherited human disease hypotrichosis simplex of the scalp. It is stored within lamellar granules, secreted and incorporated into the extracellular core of desmosomes . Corneodesmosin may play a regulatory role in the cohesion of the stratum corneum and, thus, in the maintenance of the epidermal barrier integrity
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