Biologie de la peau

Hayflick/Hayflick limit

info dans groupe Glossary

info articles lies mot

In the 1960’s, Hayflick observed that human cells displayed a finite lifespan when cultured in vitro. He later determined that most cells had a maximal capacity to proliferate in vitro of about 50 population doublings (the Hayflick limit) after which they entered what he termed cellular senescence, a process characterized by irreversible growth arrest. These observations led him to propose a cellular theory of aging whereby cellular senescence accounts for the aging process and on the contrary, escape from senescence leads to cellular transformation and cancer  . This theory is still widely accepted today although direct proof of it is lacking.


Mots-clés dans le même groupe

Autres groupes de mots-clés

Accueil | Contact | Plan du site | | Statistiques du site | Visiteurs : 3464312

Suivre la vie du site fr    ?

Site réalisé avec SPIP 3.0.17 + AHUNTSIC

Creative Commons License

Visiteurs connectés : 22