Biologie de la peau

Stem cell/stem cell/stem cells

info dans groupe Glossary

info articles lies mot

A stem cell is a cell found in all multicellular organisms that possesses two properties :

  • it can self-renew to produce more stem cell
  • it can differentiate into diverse specialized cell types.

Several types of stem cells are distinguished :

  • The totipotent stem cells   are the cells of the embryo from the fertilized egg stage to the eight-cell stage ; they can differentiate into all the embryonic and extraembryonic cell types and construct a complete, viable organism.
  • The pluripotent stem cells are the daughter cells of the totipotent cells and can differentiate into all the types of cells with the exception of the extraembryonic cell types ; they can give cells derived of any of the three germ layers (endoderm, ectoderm, and mesoderm). Pluripotency is a property of the cells that are located within the inner cell mass (ICM) of the developing blastocyst. Pluripotency in vivo and in vitro is governed by a trinity of nuclear regulators, Oct4  , Sox2  , and Nanog  .
  • The multipotent stem cells can give different types of cell but only those issued from a specific cell lineage
  • The unipotent stem cell can differentiate into only one type of cell but they can also self-renew as all the stem cells and have to be distinguished from non-stem cells.

For more details, see :

Stem cells Wikipaedia

Chambers I, Tomlinson SR. The transcriptional foundation of pluripotency. Development. 2009 Jul ;136(14):2311-22. Review. PubMed PMID : 19542351 ; PubMed Central PMCID : PMC2729344.

Articles

The stem cells

Wednesday 8 February 2012 by Michel Démarchez

Mots-clés dans le même groupe

Autres groupes de mots-clés

Accueil | Contact | Plan du site | | Statistiques du site | Visiteurs : 947372

Suivre la vie du site fr    ?

Site réalisé avec SPIP 3.0.17 + AHUNTSIC

Creative Commons License

Visiteurs connectés : 16