Caspase-14/caspase-14
Caspase-14 a member of the caspase family of cysteine proteases, is almost exclusively expressed in the epidermis ; it is detected in the upper spinous and, most strongly, in the granular layer of human epidermis, as well as in the stratum corneum . Caspase-14 is converted from a catalytically inactive proenzyme into the active enzyme, which is present in high amount in human stratum corneum. It has been recently proposed to be involved in the establishment or maturation of corneodesmosomes, the cornified envelope and keratin filaments embedded in the corneous material of mature corneocytes. It might also be implicated in the maturation of keratohyalin and trichohyalin granules.
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