Hayflick/Hayflick limit
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In the 1960’s, Hayflick observed that human cells displayed a finite lifespan when cultured in vitro. He later determined that most cells had a maximal capacity to proliferate in vitro of about 50 population doublings (the Hayflick limit) after which they entered what he termed cellular senescence, a process characterized by irreversible growth arrest. These observations led him to propose a cellular theory of aging whereby cellular senescence accounts for the aging process and on the contrary, escape from senescence leads to cellular transformation and cancer . This theory is still widely accepted today although direct proof of it is lacking.
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