versican/Versican
Versican, also called PG-M, is a lectican family proteoglycan that is present in the fetal, neonatal, and adult dermis in humans. It is a member of a family of large, aggregating proteoglycans that primarily bear chondroitin sulfate glycosaminoglycan side chains.Versican interacts with both fibrillin-1 and isolated microfibrils. Versican binds fibulin-1 and -2 via its lectin-like domain and localizes to cutaneous microfibrils. Versican also binds to hyaluronic acid (HA) via its N-terminal region and HA is co-distributed with elastic fibers in the dermis. Therefore, by binding to fibrillin microfibrils and HA, versican can impart viscous properties to cutaneous microfibrils. The loss of the HA-binding ability of versican followed by HA exclusion may be responsible for the pathological and phenotypical changes observed in solar elastosis.
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