Loricrin/loricrin
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Loricrin is a glycine–serine–cysteine-rich insoluble protein, synthesized in stratum granulosum, initially sequestered in loricrin granules. In the outermost layer of the SG, loricrin migrates to the cell periphery to be eventually cross-linked to several other cytosolic proteins (e.g., involucrin , small proline rich proteins , elafin , repetin, S100, and up to approximately 20 other proteins) by transglutaminase-1, to form the cornified envelope beneath the plasma membrane. Loricrin is comprising up to 80% of the total cornified envelope protein mass and accounts for much of cornified envelope mechanical resistance.
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