Biologie de la peau

Vitronectin/vitronectin

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Vitronectin is a multi-functional 75 kDa glycoprotein that is found in the circulation where it contributes to hemostasis by regulating blood coagulation   and fibrinolysis ; it forms a major component of the extracellular matrix where it plays major roles in cell adhesion, pericellular proteolysis, angiogenesis, tissue invasion and metastasis.

Vitronectin binds to a number of ligands including integrin receptors, heparin, plasminogen, plasminogen activator inhibitor-1 (PAI-1), thrombin–anti-thrombin (TAT) complexes, glycosaminoglycans, collagen, complement, and the urokinase plasminogen activator receptor (uPAR) and IGF-II . VN is also involved in the immune defence system through its interaction with the terminal complex of complement.

The insulin-like growth factor (IGF) system plays an important role in a number of disease states, such as cancer   and psoriasis, through its ability to modulate cell proliferation, attachment, and migration. Both the IGF-II:VN and IGF-I:IGFBP-5:VN complexes stimulate not only enhanced cell migration, but also enhanced cell protein synthesis in skin keratinocytes.

Bibliography

Vitronectin from Wikipedia, the free encyclopedia

Mayasundari A, Whittemore NA, Serpersu EH, Peterson CB (2004). « The solution structure of the N-terminal domain of human vitronectin : proximal sites that regulate fibrinolysis and cell migration ». J. Biol. Chem. 279 (28) : 29359–66

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