STRUCTURE AND FUNCTIONS

Desmosomes are highly specialized anchoring junctions that link intermediate filaments to sites of intercellular adhesion, thus facilitating the formation of a supracellular scaffolding that distributes mechanical forces
throughout a tissue.

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Article to be made

Article to be made

Article to be made

Langerhans cells which represent 3-6% of all cells in the epidermis, are mobile, dendritic, antigen presenting cells with a stellate appearance which reside in the suprabasal layers of the epidermis wedged in between, and in close contact with keratinocytes. Langerhans cells are derived from a mobile pool of bone marrow -derived precursors and constitute, in normal epidermis, a stable self-reproducing cell population throughout life under steady-state conditions. LCs are antigen presenting cells that may play a role either in triggering cutaneous immune activation or in sustaining cutaneous immunological tolerance depending of the environmental context.