LCs which represent 3-6% of all cells in the epidermis  , are mobile, dendritic, antigen presenting cells with a stellate appearance which reside in the suprabasal layers of the epidermis wedged in between, and in close contact with keratinocytes. LCs have dendritic processes extending between adjacent keratinocytes, to which they adhere via homophilic binding between molecules of E-cadherin, present on the surface of both cell types. Ultrastructurally, LCs have an indented or lobulated nucleus and an electron-lucent cytoplasm, devoid of tonofilaments and melanosomes.