The articles about the structure and the functions of skin and its components
Desmosomes are highly specialized anchoring junctions that link intermediate filaments to sites of intercellular adhesion, thus facilitating the formation of a supracellular scaffolding that distributes mechanical forces
throughout a tissue.
Article to be made
Article to be made
Article to be made
Article to be made
Langerhans cells which represent 3-6% of all cells in the epidermis, are mobile, dendritic, antigen presenting cells with a stellate appearance which reside in the suprabasal layers of the epidermis wedged in between, and in close contact with keratinocytes. Langerhans cells are derived from a mobile pool of bone marrow -derived precursors and constitute, in normal epidermis, a stable self-reproducing cell population throughout life under steady-state conditions. LCs are antigen presenting cells that may play a role either in triggering cutaneous immune activation or in sustaining cutaneous immunological tolerance depending of the environmental context.
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